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Showing posts with label stroke. Show all posts
Showing posts with label stroke. Show all posts

08 June 2026

Donald Trump 'suffered a stroke' in disastrous appearance - and expert warns it will get worse 7JUN26


 MORE proof NOT MY pres drumpf's/trumps recent medical exams have been cognitive test NOT IQ test due to his extreme erratic ( even for him ) behavior. This is what the 25th amendment is for, there has to be someone in the corrupt neo-nazi fascist drumpf/trump-vance administration or in the corrupt gop/greed over people-republican party with the courage to declare drumpf/trump unable to continue his term and initiate the steps to remove him from office. Most likely his family and cabinet and billionaire backers will keep him there while they complete all their insider trading and pillaging of the nation. From The Mirror.....

Donald Trump 'suffered a stroke' in disastrous appearance - and expert warns it will get worse


A physical therapist offering a detailed point-by-point analysis of the presidential health footage


US President Donald Trump's health has once again sparked significant concern after a physical therapist indicated the American leader, nearing 80, may have suffered a "stroke-like event".

In a post to his Instagram page yesterday (June 5), Adam James, who creates content as @epistemiccrisis and specializes in geriatrics, stated: "Don Snorleone had a stroke on camera yesterday."

James then provided a detailed, point-by-point medical-style examination of Trump's recent public appearance at an Oval Office press briefing on "clean coal" on Thursday (June 4). It comes after Trump had a meltdown and stormed out of the interview for a crazy reason.

James, who possesses a doctorate in his field with 14 years of professional experience, argued that Trump suffered a "stroke-like event or a stroke on camera" after the president remained largely out of public view for six days, from May 27 to June 3.

"He suffered a stroke and they were trying to get him to recover enough to go back on camera," James said. He further explained: "Number one is this posture", reports the Irish Star.

"I've had so many stroke patients over the years that the stroke has affected the strength and the tone of the muscles on one side of their trunk and they cannot maintain upright posture. But when he's very fatigued and falling asleep, he's going to lean to one side."

The content creator continued: "That right there was the worst instance of expressive aphasia, a common symptom of left sided stroke on the left side of the brain where your language centers are, I have ever seen from him to date. Did you hear him mumble through those words?

"And then he follows it up with 'good', he reaches for a very simple word because he knows 'I can't talk right now'. Expressive aphasia is different from phonemic paraphasia which is a typical dementia symptom but he got dementia and a history of stroke.

"So it's kind of tough to tell sometimes, but that sounded like expressive aphasia. Now, in this next clip, I want you to watch his jaw slightly shift left and right.

"The more that his jaw shifts to his right, the more asleep he is because he has a right-sided facial droop from a history of stroke. And his jaw is becoming weaker and more slack-jawed also because of dementia.

"But you can literally see his jaw slip in and out of awake, asleep, awake, asleep. I am so delighted because this is the worst I have ever seen him."

James concluded: "And I can't wait for it to get worse. At this point, he's on 43 days of borrowed time." In the video James examined, Trump was taking part in an official administration event focused on deregulation and environmental policy, with specific emphasis on "clean coal".

During the briefing, Trump spoke to reporters before passing the floor to Interior Secretary Doug Burgum and Environmental Protection Agency Administrator Lee Zeldin.

As Burgum and Zeldin gave their presentations, Trump leaned back in his seat and appeared to close his eyes, with social media users claiming he looked like he was falling asleep.

There has never been official confirmation that Trump has suffered a stroke, dementia or any other neurological disorder, despite persistent speculation on the internet.

The White House and Trump's physicians have repeatedly rejected such claims, saying public conjecture is not supported by medical evidence.


24 May 2025

What Your Blood Type Says About Your Health 31OKT24



JUST a FYI, and by the by I am O- This from AARP

What Your Blood Type Says About Your Health


Published February 21, 2023
/ Updated October 31, 2024

Do you know your blood type? There’s a good chance that you don’t. More Americans know their horoscope sign (66 percent) than their blood type (51 percent), according to a survey published last year by laboratory company Quest. There are compelling health reasons why you should know, especially when it comes to your heart. Research suggests that people with certain blood types — namely A and B — are at higher risk to develop blood clots and to have heart attacks and strokes.

“We think about blood type a lot when we think about transfusions,” says Robert Salazar, M.D., a cardiologist at Memorial Hermann Health System in Houston. There may be some benefits to know about it for heart health, he adds. “Increasingly, there is a push towards the individualization of medicine and medical advice,” he explains. Adding information about blood type, he says, may help inform doctors on how to best treat patients.

Types of blood

Blood Type and Your Health

What the research shows:

Types A and B: Higher risk of blood clots, heart attacks and strokes.
Type AB: Higher risk of stroke and inflammation. Those with AB+ blood can accept blood from all donors and are called universal recipients.
Type O: Slightly lower risk of thrombosis, blood clots, heart attacks and strokes. People with type O- blood are universal donors and can donate to anyone.

Note that a healthy lifestyle likely trumps blood type in terms of increasing or decreasing risks.

Blood types are determined by the presence or absence of certain substances, called antigens, that can trigger an immune response if they are foreign to the body. 

There are four main blood types: A, B, O and AB, according to the American Red Cross. In addition to these antigens, there’s a protein called the Rh factor, which can either be present (+) or absent (-). That means there are eight blood subtypes: A+, A-, B+, B-, O+, O-, AB+, AB-.

Types A and B and blood clots

People with blood types A and B are at higher risk to develop blood clots compared with people who have type O blood, according to a 2020 study published in the American Heart Association journal Arteriosclerosis, Thrombosis, and Vascular Biology. The study, which looked at more than 400,000 people, found that types A and B were 50 percent more likely to develop blood clots in the legs called deep vein thrombosis and 47 percent more likely to develop a pulmonary embolism — when a clot travels to the lungs — than people with type O blood. They were 8 percent more likely to have a heart attack and 10 percent more likely to experience heart failure than type Os.

Why blood type affects clot risk

There are many possible reasons for why this happens, says Mary Cushman, M.D., a hematologist at the University of Vermont Medical Center and a professor of medicine and pathology at the Larner College of Medicine at UVM in Burlington, Vermont. ​​ 

“The enzyme that controls blood type has other actions,” she explains. One of these is to modify a protein called von Willebrand factor, which is very important in forming blood clots. “The modifications to the protein are different in different blood types,” she says. “So people with type O blood have the lowest levels of von Willebrand factor on average and the lowest risk of abnormal clots. Type AB has the highest level and, in some studies, the highest risk of blood clots.” ​​

There may also be some differences in platelets, the small cell fragments in the blood that form clots, says Joshua Beckman, a cardiologist at the UT Southwestern Medical Center. This may make you more susceptible to clotting.

Type A, type AB and cholesterol, stroke

There’s evidence to suggest that type A blood is linked to higher levels of low-density lipoprotein (LDL) cholesterol, the waxy substance that clogs arteries. Type AB blood is linked to inflammation, which may adversely affect blood vessels. Larger studies need to be done before coming to any definite conclusions, Beckman says.

Blood type may impact stroke risk, too. A 2022 study published in the medical journal Neurology reviewed 48 studies of 17,000 stroke patients and found that people with type A were 16 percent more likely to have an early stroke than people with other blood types, and those with type O were 12 percent less likely. An earlier study done by Cushman found that blood type AB, compared with O, had a 1.8 times higher risk of stroke; other blood types weren’t affected.

Blood type and COVID-19 risk

Scientists are studying how blood type might affect risks from the COVID-19 virus, but they say it’s too early to draw firm conclusions. One Danish study, published in Immunobiology, for example, found that among hospital workers exposed to COVID-19 from April to September 2020 —when the vaccine wasn't out yet and the workers did not have personal protection — those with type O had a lower risk of getting the virus. Research has also linked type O blood with a lower chance of getting seriously ill from cholera, and it may offer some protection from severe malaria.  

What you can do

It’s important to keep research findings in context. Though certain blood types could mean an increased chance of health problems such as blood clots and stroke, the risk is relatively small compared with the dangers of smoking and high blood pressure, and blood type doesn’t tell you much about your personal risk, Cushman points out.

You also shouldn’t let your blood type give you a false sense of security. If you’re having surgery or if you have cancer — both situations that can raise the risk of blood clots — Cushman recommends that you talk to your health care provider about a blood clot prevention plan. “If you have O blood type, you may have slightly lower risk of some diseases like thrombosis, but it doesn’t completely protect you from the risk,” she says. Thrombosis occurs when clots block blood vessels.

Knowing your blood type may give you added insight into your heart health, Salazar says. Though doctors often talk about manageable risk factors, such as high blood pressure, diabetes and smoking, there’s less conversation around genes or the genetic risk for heart disease, he says. Having a patient’s blood type is a “way to try to narrow down individuals who may be at high risk,” he says. For these people, following the American Heart Association’s Life’s Essential 8 — eating right, staying active, not smoking, getting enough sleep, managing weight, controlling cholesterol, managing blood sugar and managing blood pressure — may be even more important.

Regardless of your blood type, everyone should have a heart-healthy lifestyle, Cushman says. “Following the guidance of the American Heart Association’s Life’s Essential 8, for example, will add years to your life and reduce your risk of thrombosis-related outcomes like heart attack, stroke and venous thrombosis,” she says.

How to find out your blood type

A simple blood test can reveal your blood type. If you’re curious, you can ask your doctor to have it tested the next time you need bloodwork. There’s another very quick and easy way to figure out your blood type that’s also altruistic: Give blood.

A 2019 national survey conducted by the Red Cross found that more than half of people believe they need to know their blood type to do so, but that’s not true. Once you give blood, you’ll learn your blood type when you receive your donor cord, and you can create a profile through the Red Cross Blood Donor App. Slightly more than a third — 37 percent — of the world’s population has the most frequently occurring blood type, O+.

Editor's note: This article, originally published February 21, 2023, has been updated with new information.

03 July 2018

Coffee Drinkers Are More Likely!! 2JUL18

Image result for BEFORE I HAVE COFFEEImage result for BEFORE I HAVE COFFEE
YES! YES! OH YES! OH HAPPY DAY! OH MY YES!!! I knew all my years of grinding my beans fresh every morning, the ice cold water and then chanting while it brewed with incense burning and the occasional bang on a gong or ringing of bells was going to pay off!!!!!!

Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too

Coffee is far from a vice.
There's now lots of evidence pointing to its health benefits, including a possible longevity boost for those of us with a daily coffee habit.
The latest findings come from a study published Monday in JAMA Internal Medicine that included about a half-million people in England, Scotland and Wales. Participants ranged in age from 38 to 73.
"We found that people who drank two to three cups per day had about a 12 percent lower risk of death compared to non-coffee drinkers" during the decade-long study, says Erikka Loftfield, a research fellow at the National Cancer Institute.
This was true among all coffee drinkers — even those who were determined to be slow metabolizers of caffeine. (These are people who tend to be more sensitive to the effects of caffeine.) And the association held up among drinkers of decaffeinated coffee, too.
In the U.S., there are similar findings linking higher consumption of coffee to a lower risk of early death in African-Americans, Japanese-Americans, Latinos and white adults, both men and women. A daily coffee habit is also linked to a decreased risk of stroke and Type 2 diabetes.
What is it about coffee that may be protective? It's not likely to be the caffeine. While studies don't prove that coffee extends life, several studies have suggested a longevity boost among drinkers of decaf as well as regular coffee.
So, researchers have turned their attention to the bean.
"The coffee bean itself is loaded with many different nutrients and phyto-chemicals," nutrition researcher Walter Willett of the Harvard School of Public Health told us in 2015. These compounds include lignans, quinides and magnesium, some of which may help reduce insulin resistance and inflammation. "My guess is that they're working together to have some of these benefits," Willett said. (He's the author of a study that points to a 15 percent lower risk of early death among men and women who drink coffee, compared with those who do not consume it.)
"Coffee, with its thousand chemicals, includes a number of polyphenol-like, antioxidant-rich compounds," says Christopher Gardner, who directs nutrition studies at the Stanford Prevention Research Center. He says there's so much evidence supporting the idea that coffee can be a healthy part of your diet, it's now included in the U.S. Dietary Guidelines. In 2015, the experts behind the guidelines concluded that a daily coffee habit may help protect against Type 2 diabetes and cardiovascular disease.
Gardner says part of the benefit of coffee may be linked to something profoundly simple: It brings people joy.
"Think about when you're drinking coffee — aren't you stopping and relaxing a little bit?" Gardner asks.
He says it's such a simple pleasure. "I just love holding that hot beverage in my hand. It's the morning ritual," he says. He drinks at least three cups a day.
So, how did coffee achieve such an image makeover? It wasn't too long ago that coffee was considered a vice.
Gardner says the bad rap goes back to a time when people who drank coffee were also very likely to smoke cigarettes. 

So, when earlier epidemiological studies suggested that coffee consumption was associated with health risks, researchers were thrown off. It wasn't until they separated these two habit apart that a completely different picture emerged.

"Smoking was the cause of the association," Gardner says. "Ever since they disentangled smoking, coffee wasn't just null, it was [shown to be] beneficial."

12 March 2014

The Risks And Benefits Of Prescribing Testosterone 6FEB14

I think every man should listen to or read the transcripts of this show before starting and if they have started testosterone treatment. My younger brother (he's 55 years old) started getting injections last year. I talked to him about this show, sent it to him, and he is going to talk to his doctor. He said she NEVER mentioned anything about risk and side effects. This is what made me afraid for him "
...but you don't know how many men had injections. And the injections are the ones that are at the highest risk of having heart attacks and strokes. For example, when we give an injection, we get a super normal testosterone bump. And those are the men that I worry about in my practice. And I constantly get red blood cell counts, hematocrits, because that's where you see an increase in red cell count and a higher chance of having heart attacks and strokes. I'm very worried about those people." This article is definitely worth sharing. From WAMU's Diane Rehm Show.....
Listen to the show here http://thedianerehmshow.org/audio-player?nid=18847

MS. DIANE REHM

10:06:53
Thanks for joining us. I'm Diane Rehm. Recent studies show a higher risk of heart attack and stroke in older men who use prescription testosterone. Last week, the FDA said it's reassessing the safety of the hormone. Joining me in the studio to talk about risks and benefits of using testosterone, Dr. Adriane Fugh-Berman of Georgetown University Medical Center.

MS. DIANE REHM

10:07:24
Joining us from an NPR studio in New York, Dr. Harry Fisch of New York Hospital and Cornell University, and Roni Caryn Rabin, a journalist who covers medicine and health. I'm sure many of you will have your own thoughts, your questions. Join us on 800-433-8850. Send us your email to drshow@wamu.org. Follow us on Facebook or send us a tweet. And thank you all for being with us.

DR. ADRIANE FUGH-BERMAN

10:08:00
Delighted to be here.

REHM

10:08:02
And, Roni Rabin, if I could start with you, tell us about these most recent studies regarding prescribing testosterone.

MS. RONI CARYN RABIN

10:08:16
The study that came out last week that got everyone's attention said that heart attacks doubled in men who were 65 and over within 90 days of getting their first prescription of testosterone and nearly tripled in younger men who had had a history of heart disease also within that 90-day period. And it wasn't the first study. There have been other studies, observational studies, randomized controlled trials that were analyzed that have sent this signal as well. So this alarmed a lot of people.

REHM

10:08:44
I would wonder why there are so many more people taking testosterone. What does the research tell us, Roni?

RABIN

10:08:59
Well, it's become a huge business. This has become a $2 billion business in the United States over the last decade or so. There's been an enormous amount of money pumped into advertising, not just advertising specific drugs, but these campaigns to raise awareness about a disease or a condition. And at this point, nearly one in 25 men in their 60s is taking testosterone. Use has nearly quadrupled among men 40 and over.

REHM

10:09:32
And, Dr. Fugh-Berman, the question becomes what is the difference between the so-called Low T that we hear so much about on television and low testosterone?

FUGH-BERMAN

10:09:53
Well, Diane, the term low T was actually invented by pharmaceutical companies in order to broaden the market that was eligible to receive testosterone. So the condition is called Low T to consumers. Usually, with physicians, they call it late onset hypogonadism, but it's really different than true hypogonadism where somebody might have a pituitary tumor or was born without testes or with un-descended testicles, for example.

FUGH-BERMAN

10:10:27
So there are instances in which somebody should have testosterone therapy. But normally, aging men should not be taking testosterone therapy. Not only are there the risks that Roni has discussed, but there's also no evidence of benefits, really. So it's really being over-promoted among normal men. The imputed benefits are not real, and the risks are very real.

REHM

10:11:05
Now, turning to you, Dr. Fisch. I understand that Low T is talked about in terms of feelings of fatigue, loss of sexual drive, depressed moods. In a situation like that, how are you prescribing testosterone?

DR. HARRY FISCH

10:11:33
Well, there's a couple of things I would -- Dr. Fugh-Berman was saying there are no studies that show a benefit. There are studies that show benefits of men who actually have low testosterone. And I agree with Dr. Fugh-Berman about, you know, people who have very low levels of testosterone, such as pituitary tumors or testicular problems, can benefit dramatically from medications.

DR. HARRY FISCH

10:11:54
And there's no question about those people. The question occurs as men get older and if they have hypogonadism. Clearly, men who are getting older and are fatigued and have other issues, such as you just mentioned, may not need any medication. They may need other more natural approaches to treatment. But if they do have low testosterone, that's an indication, that's a red flag that something more serious is going on and needs to be addressed.

REHM

10:12:21
How rare, Dr. Fisch, are those individuals with a truly medical problem?

FISCH

10:12:31
Well, there are quite a bit of people that have true medical problems that manifest with a low testosterone. For example, there was studies that show about 40 to 50 percent of diabetic men have low testosterone. Obesity is associated with low testosterone, as is chronic fatigue. Now, that doesn't mean -- I want to make a point here. That doesn't mean because they have diabetes, low testosterone, just treat the low testosterone, not the diabetes.

FISCH

10:12:55
We always tell people, you know, to change their lifestyles, diet, exercise, of course, in addition to sleeping more. For example, the number one cause of fatigue in young men and older men, ready for this, is lack of sleep. So the first thing we tell people is to sleep. Testosterone is made when men sleep. So in this country where we're sleeping five to six hours a night when we should be sleeping eight to 10 hours a night makes a big difference.

FISCH

10:13:20
So simple information like that, as well as dietary changes. But, unfortunately, a lot of men may not be able to make those changes and in many times, we do provide medication to help them along.

REHM

10:13:33
Dr. Fisch, going back to my original question, I'm wondering how frequently you prescribe testosterone.

FISCH

10:13:43
Well, my practice is one where I do prescribe medications to increase a body's production of testosterone, and it -- is it rare? Well, it is not rare. As I said, 50 percent, about half of men who have diabetes have low testosterone. So but the importance is when you say prescribe testosterone, in my practice -- and I'm supposed to be the guru of testosterone therapy. That's what I'm known for in some respects.

FISCH

10:14:10
And most of the patients that I treat I don't treat with testosterone and that's a very important distinction. Just like Dr. Fugh-Berman said, you know, some people who have very low testosterone and are clear indications for sure those people need testosterone shots or gels, but for the vast majority of the so-called late onset hypogonadism, I treat with lifestyle changes, basic information on diet, but also with a drug called clomiphene citrate. And probably 70 percent of my patients are on a medication that's a generic medication that allows the body to produce its own testosterone.

REHM

10:14:47
All right. Dr. Fisch, I want to ask Roni Rabin specifically about Viagra and Cialis. Were they somehow exonerated in these studies of testosterone?

RABIN

10:15:08
Well, the PLOS-1 study did compare the testosterone effects with Viagra effects, I mean, not directly. It was in a randomized clinical trial, and it did try to tease out whether this effect of the cardiovascular problems was due to a suddenly ramped up sex life perhaps, as opposed to the actual drug. And they did find that this was an effect of the testosterone, not the Viagra.

REHM

10:15:36
All right. And to you, Dr. Fugh-Berman, what about AndroGel?

FUGH-BERMAN

10:15:43
Well, I need to say that determining what low testosterone is, that's not actually established in medicine. That in studies that have looked at low testosterone, they've picked all kinds of different levels. Testosterone levels vary by lab. There's wide ranges of normal testosterone levels in every age group so while a group of 80 year olds will have lower testosterone that a group of 20 year olds, in every age group, there will be a very wide range. There's no connection between testosterone levels and symptoms, and all of these symptoms are quite nonspecific, of course, things like...

REHM

10:16:20
Such as?

FUGH-BERMAN

10:16:21
Such as fatigue or diminished sports performance or diminished body hair. Some of the Low T tests asks, are you sad and/or grumpy? Everybody in my office failed the Low T quiz, including the 25-year-old women. But -- and that quiz was actually invented by a physician who was being paid by pharmaceutical companies and apparently wrote the quiz on toilet paper.

REHM

10:16:53
But what about the question of erectile dysfunction?

FUGH-BERMAN

10:16:58
Oh, yeah, great question. So testosterone doesn't actually work for erectile dysfunction. So while there is evidence that testosterone increases libido, it does not increase sexual function, which just seems like a more frustrating situation to me.

REHM

10:17:13
What does it do?

FUGH-BERMAN

10:17:15
Well, in very high doses, it has an effect on muscle. AndroGel and these other popular gels that are being used in people who aren't bodybuilders, it may not even do that. That's a little unclear, but in a study several years ago where testosterone gel was given to men over 65 because it was hoped that they could carry packages up steps faster and just walk around more easily, that study was actually stopped early because of increased cardiovascular events.

FUGH-BERMAN

10:17:49
So it was stopped because the treatment was dangerous. As Roni has pointed out, there have been a number of studies now showing an increased risk of cardiovascular events with testosterone and those aren't the only risks. It also increases the risk of prostate enlargement, congestive heart failure, male breast cancer, possibly prostate cancer, and pulmonary embolism or blood clots.

REHM

10:18:15
So there are lots of issues associated with testosterone, the first being the question of how to determine low testosterone. Short break here and when we come back, we'll take your calls, your email. Stay with us.

REHM

10:20:00
And welcome back as we talk about benefits and risks of testosterone use which prescription testosterone has gone up dramatically in the last ten years or so between 2001 and 2011. Hormone use by men over 40 nearly quadrupled. Here's an email. "My husband," she says, "of 20 years was removed from a restaurant after jumping up, drawing back his fist and shouting that he was going to hit me. He had been taking testosterone for a few months and had just had his dose increased. He had never done anything like this before."

REHM

10:20:58
She goes on to say, "I believe this therapy is dangerous. Our doctor admitted it can cause aggression, as did the domestic abuse hotline I called. What does the research say?" Dr. Fisch, can you talk about that?

FISCH

10:21:19
Well, let's be honest, Diane. That's one case. I mean, I've treated thousands of men with this, and I have never seen that. The issue is -- that we brought up before -- how do you diagnose the low testosterone hypogonadism? And should men be treated who have normal testosterone levels? That's really the bottom line, because you don't know if that man that you were just describing was over treated, and it's very important.

FISCH

10:21:42
And what Dr. Fugh-Berman said was absolutely correct. You know, there is no defining testosterone level by which we can say that somebody is hypogonadal. And there is no symptom per say that we could say, ah, that person has low testosterone. Hypogonadism is a clinical situation that requires both a low testosterone level and clinically relevant symptoms together, not one or the other.

FISCH

10:22:05
So people should not be screened for just testosterone levels because the truth is, it brings up issues that they're not aware of and they may be over treated in those patients. And what I mean by that is, in the article in the Plus One study that we're talking about today where there's an increase incidence of heart attacks and strokes, the bottom line of that study was that during that study they didn't even know which men -- or what the testosterone levels were in the men that were treated at the VA hospital.

FISCH

10:22:34
And we know that men are being treated who have normal testosterone levels. Studies have come out that showed well over one-third of men who are receiving therapy -- testosterone therapy have normal testosterone levels. So back to your statement, if you're going to take a person who has normal testosterone levels and you're going to increase their testosterone levels above normal, well, you know, those have risks associated such as heart attack, stroke, aggression.

FISCH

10:22:59
But if we're trying as doctors -- and I -- as I said, I treat thousands of men. This is my specialty -- we want to maintain the testosterone levels in the normal range only. And when we do that...

REHM

10:23:09
All right. Dr. Fisch, I want to be clear about one thing. Are you paid by the company that produces AndroGel?

FISCH

10:23:21
I am not paid by any company at this point. In the past, I was paid by AbbVie to actually bring product awareness -- disease awareness, I should say. But I've never ever talked about a specific drug per se.

REHM

10:23:34
Are you on the website that is associated with...

FISCH

10:23:37
Yes, I am.

REHM

10:23:40
...AndroGel or any of the other drugs?

FISCH

10:23:43
I am on the AbbVie -- or it's called AbbVie website and is at lowT.com website where I discuss the disease itself, but not which drugs to take. And as I said...

REHM

10:23:53
All right. All right. And to you, Dr. Fugh-Berman.

FUGH-BERMAN

10:24:00
Well, we don't really know what normal testosterone levels are.

REHM

10:24:04
How is that? How come?

FUGH-BERMAN

10:24:06
Well, for one thing, well they vary widely in individual men but they also vary by the hour. They vary by the day. They're generally highest in the morning. They can actually increase with job status. They can increase with exercise. They can increase with whether your sports team won or lost that day. So there are many factors that increase or decrease testosterone levels. Caretaking apparently decreases testosterone levels.

FUGH-BERMAN

10:24:34
But, you know, to return to your reader's comment, testosterone can increase aggression, and not just in people but also in pets. Since these gels are sometimes rubbed on the chest or other places where someone might come into contact with a child or a pet, this is actually caused...

REHM

10:24:54
Well, that's a warning, isn't it?

FUGH-BERMAN

10:24:56
Yeah, it...

REHM

10:24:56
I mean, isn't there a warning on the ad that says, make sure that you as a woman, if you're pregnant, you do not touch that site?

FUGH-BERMAN

10:25:09
Right. Or -- and children as well. If a man is hugging his child, there might be gel that gets on the child. And even pets who've been handled by men who've been using testosterone sometimes become more aggressive.

REHM

10:25:24
Now here's another email from James in Orange, Va. who's 60 years old. He says, "I watched one of those ads last night on TV. The side effects were laughable, swelling, bleeding, headaches. Don't let women and children touch that spot where testosterone was applied. I cannot," says James, "imagine that, given proper notification of the potential side effects, any sane person would choose to take this drug. What could be the benefits?" Roni, let me ask you that. Did researchers find benefits?

RABIN

10:26:16
There's actually a big NIH trial going on right now at University of Pennsylvania to look at the benefits. And that's one of the questions in IOM report, an Institute of Medicine report about a decade ago said was still actually a question, what are the benefits? But, Dr. Fisch, do you want to add to that?

FISCH

10:26:35
Oh, I'd love to add to that. You know, my patients who have low testosterone, primary testicular failure that cannot make testosterone, this is a life-saving medication for them. And, I mean, that because literally these people who have no -- are unable to make their own testosterone benefit dramatically: their increased energy level, muscle mass, less of a chance to get diabetes, more exercise tolerance.

FISCH

10:27:02
And, you know, I've been -- my patients have been written up in magazines about this. So while you're presenting patients that have dramatic side effects, I could present tons of patients, and I mean tons -- tons was by weight -- maybe thousands of patients that actually have benefitted by the testosterone levels.

REHM

10:27:16
All right. Dr. Fugh...

FUGH-BERMAN

10:27:17
But, Dr. Fisch, you also mentioned that people who don't have low testosterone who are given exogenous testosterone as a drug, what happens to them?

FISCH

10:27:26
Well, first of all, I consider that malpractice. If some doctor is treating patients who have normal testosterone levels and not -- or not even checking their testosterone levels, well that is not the approach that I take. It's not the approach that the Endocrine Society recommends or anybody recommends...

REHM

10:27:42
All right. Dr. Fugh-Berman.

FISCH

10:27:43
...because that's just treating them and getting complications.

FUGH-BERMAN

10:27:46
Yeah, a couple of things that need to be said. One is that testosterone may improve mood, which of course will make people feel better about a lot of things. And there's a very strong placebo effect. Things like libido and fatigue and mood are very amenable to the placebo effect. And this is a very dangerous placebo. But the other thing about health benefits, I'd really disagree with you there, Harry. In fact, we know from studies of eunuchs who have had their testicles removed that they actually live longer than people with normal testicles.

FISCH

10:28:25
Well, I don't treat eunuchs but I can tell you that patients that I see that develop testicular failure are in a terrible situation in terms of depression, low muscle mass. As I said, a lot of them are overweight. I've had tremendous success in men. We talk about, you know, mood, sex drive and everything.

FISCH

10:28:41
But it turns out that, in order to lose weight, I see tremendous weight loss and consistent weight loss in men who have normal testosterone levels. And in the general medical community, we know that anybody can lose weight, but it's maintaining the weight loss over time. We don't want those yo-yo diets. We want to build muscle mass and maintain people's ability to maintain that weight loss. And I've had -- I treat patients like this. And I've had tremendous success with it.

REHM

10:29:04
All right. Are there any -- are there side effects, Dr. Fisch, that you can talk about?

FISCH

10:29:11
Yes. Yes. There's very important side effects, and some of the studies including the Plus One study and the past studies are very important to discuss. Every testosterone therapy is not the same. Everyone is different. For example, the gels are different than injections. And in this study that just came out, we don't know how many men were on injection therapy as opposed to just gel therapy. Now why is that important?

FUGH-BERMAN

10:29:35
The most common treatment was gel in the (unintelligible)...

FISCH

10:29:38
I didn't see that in the -- yeah, but I...

FUGH-BERMAN

10:29:40
It states in the paper.

FISCH

10:29:42
...but you don't know how many men had injections. And the injections are the ones that are at the highest risk of having heart attacks and strokes. For example, when we give an injection, we get a super normal testosterone bump. And those are the men that I worry about in my practice. And I constantly get red blood cell counts, hematocrits, because that's where you see an increase in red cell count and a higher chance of having heart attacks and strokes. I'm very worried about those people.

REHM

10:30:05
All right. I want to open the phones now, 800-433-8850. Let's go first to Dan in Asheville, N.C. Hi, you're on the air.

DAN

10:30:22
Hi, Diane.

REHM

10:30:23
Hi there.

DAN

10:30:25
I have a brother who has -- OK, he's 35 years old, and he's been taking testosterone for the past two years. And it just seems like -- I'd like the panelists to discuss maybe the personality changes that a person goes through. Because he just keeps -- he's having problems with his family. He's having problems with his coworkers.

DAN CALLER)

10:30:49
And it just seems like the doctor who's prescribing it, the testosterone, just keeps upping and upping his dosage as he goes along. He started off with the cream, and now he's gone to shots. And it just seems like all the problems that he's has in the past two years with taking the testosterone has correlated it with when he started.

REHM

10:31:11
Dan, do you have any idea why he went to the doctor in the first place? Why this was prescribed at all?

DAN

10:31:23
From what I understand, Diane, he was just like your panelists were discussing before. He was just chronically fatigued. He was, you know, he was just kind of "depressed" a little bit.

REHM

10:31:34
That's interesting. All right. Dr. Fugh-Berman.

FUGH-BERMAN

10:31:37
Testosterone is not an appropriate treatment for depression or fatigues. We have better, safer treatments for that. And there's actually no evidence that testosterone actually helps either of these things. So that's a really concerning story. It'd be great if you could convince him to go off and maybe change doctors.

REHM

10:31:56
What would...

DAN

10:31:56
I mean, the thing is, when we try to talk to him about it, he's almost as if he's become addicted to the testosterone. He doesn't want to talk about it. He doesn't -- he thinks the testosterone has helped him. And, you know, it feels like he's on steroids almost.

FUGH-BERMAN

10:32:13
He -- well, he is on steroids. Testosterone is a steroid. And it would be maybe -- maybe pointing out some of the risks like a heart attack might be useful for him. But that's a very concerning story. And unfortunately there is all of this promotion that is going on in medicine, the physicians as well, to convince them that it's OK to give testosterone to men who don't need it. And there may be other undiagnosed medical problems like depression that really -- they're important. They need to be treated, but they do not need to be treated with testosterone.

REHM

10:32:50
Roni, can you tell us about the studies of the older men and the kinds of symptoms they presented with?

RABIN

10:33:04
Well, there was a randomized control study quite a while back that was stopped by safety monitors. It was a small study. It was one of those with a control group that received a placebo. They -- and these were older frail men, frail elderly men. And they were giving them testosterone. And so that they -- the ones receiving the testosterone really did gain strength in their chests and their legs. They were able to walk upstairs faster. They were able to carry things. But they did start having heart attacks at high rates.

REHM

10:33:34
Wow.

RABIN

10:33:35
And the safety monitor saw this and put an end to the trial. That was quite some time ago. There were questions about how old and frail these men were, and whether the doses they received were correct. But that was done probably, you know, quite -- several years ago.

REHM

10:33:54
All right. And you're listening to "The Diane Rehm Show." Let's go to Gary in Arlington, Va. You're on the air.

GARY

10:34:05
Yes. Thanks so much for taking my call.

REHM

10:34:07
Sure.

GARY

10:34:08
I am 63 years old and I've been on testosterone gels for four years. When I was 59 I was just feeling old and cranky and there was no joy in life. And I mentioned this to my doctor, you know, during my routine physical. And he took, you know, of course, the blood work, and, sure enough, I was very, very low in my testosterone count. And, you know, I just feel like a new person within two or three weeks of starting it.

REHM

10:34:40
Mm hmm. Now what about that Dr. Fugh-Berman? Can a doctor simply measure that testosterone level through the blood and assume that that's the problem?

FUGH-BERMAN

10:34:57
Not really. Not only do the levels vary by what lab you send it to, but it also varies by the hour and varies by the day. And we don't really know what a normal range is.

REHM

10:35:09
OK. But Gary is 63. He says he's felling lots better. Dr. Fisch, I would assume that you would attribute that to the testosterone.

FISCH

10:35:24
Of course. A lot of my patients are like that. And again, I treat these patients. And what I want to make a point about what Dr. Fugh-Berman said, if we have consistently abnormally low testosterone based on what the FDA has allowed under 300 anagrams per deciliter, now that is not the best level for sure, but it is what we have for now. In association with symptoms, treatment of those patients reveal what Gary just said, and that is tremendous increase in strength and libido sometimes and ability to lose weight.

FISCH

10:35:56
But the thing that I find most fascinating is cognitive function changes. I've had people that tell me -- geez I had one patient said to me, you know, when he came after I started treatment he said, you know Dr. Fisch, now I can read again. I said, what? I didn't even know -- what do you mean now you can read again? He said, I didn't have the concentration ability to read again. So now he's able to read. He's able to concentrate.

FISCH

10:36:15
And when it comes to depression, let me make a point that the symptoms of depression and low testosterone overlap. They're very, very similar. And we now know that men who are depressed tend to have low testosterone levels. So the future...

REHM

10:36:26
Roni, I wonder if you found that in any of the studies that you went back to look at.

RABIN

10:36:36
Well, I'm -- there are a couple things I just want to say. First of all, the caller -- it was a little bit déjà vu. You know, in medicine you're always trying to balance the benefits and the risks. And this idea that you take something that makes you feel great, we heard that for years about hormone replacement therapy for women during menopause. For years, we thought that was terrific.

RABIN

10:36:59
It would prevent heart disease in women. It would keep them healthier for longer and keep them vital and having great sex lives and their skin and everything. It was supposed to be the magic pill. It turned out not to be the case. We actually found out once we did randomized controlled trials that there were a lot of risks to that. And I think we need to be careful.

REHM

10:37:18
All right. We've got to take a short break here. Roni Caryn Rabin is a medical reporter for the New York Times. When we come back, more of your questions, comments. Stay with us.

REHM

10:39:58
And in this hour we're talking about testosterone, the prescribed medication given to men, and indeed some women are using it. We invited the makers of several of the top-selling testosterone drugs to be on the program. Most were not able to get back to us before the program began. But Eli Lilly, maker of Axiron, sent a statement. It reads in part, "Axiron is a prescription medication approved by the FDA for men with certain conditions associated with a deficiency or absence of testosterone.

REHM

10:40:49
"Lilly does not condone the use of our medication for off-label purposes. Patient safety is Lilly's top priority. They actively monitor all adverse events, including cardiovascular events reported in clinical studies and clinical use. Lilly continues to review available safety information, including cardiovascular safety information to determine if updates to the Axiron label are needed." Dr. Fugh-Berman, would you be in favor of a big or larger warning label on drugs containing testosterone?

FUGH-BERMAN

10:41:45
Well, there's certainly does need to be a change in the warning label. And in fact, the FDA has announced that it is going to look into these adverse events that have been really cropping up in a lot of studies lately. And by the way, the FDA does not make a mention of what testosterone level in the blood should be treated.

REHM

10:42:05
So give me a range in numerical terms of what one might see as a range of testosterone levels.

FUGH-BERMAN

10:42:19
So it could be anywhere from zero in somebody who doesn't have testicles, up to over 1000. And various people have said low testosterone is under 150 or 200 or 250 or 300. It's not well established what low testosterone is.

REHM

10:42:37
Dr. Fisch, how do you determine what low testosterone is?

FISCH

10:42:44
I follow the Endocrine Society guidelines.

REHM

10:42:46
What are those?

FISCH

10:42:47
And those are the guidelines that say if a testosterone is below 300, with symptoms -- I want to make an important point. It is not the level that's important. It's the level and the clinical symptoms combined. We are not sure…

REHM

10:43:01
But the clinical symptoms, Dr. Fisch…

FISCH

10:43:04
Yes.

REHM

10:43:04
…I gather you would agree, are fairly vague.

FISCH

10:43:09
They are vague, but the number one, number two symptoms are fatigue and low libido. And those are things that we see marked increases in with the treatment -- with people who have low testosterone. That's what I see in my clinical practice. So the bottom line is there are guidelines by the Endocrine Society. And in terms of warning labels, yes, the FDA -- you always have to take a look at what happens in the clinical situation, what happens in the population. But important to remember, promotion to men who do not have low testosterone is wrong.

REHM

10:43:40
All right.

FISCH

10:43:40
It is only for men that have low testosterone and symptom for a condition called hypogonadism.

REHM

10:43:45
OK. But…

RABIN

10:43:47
I think…

REHM

10:43:48
Go ahead, Roni.

RABIN

10:43:49
I'm just wondering, though. Men's testosterone levels do seem to decline with age in a normal age-related decline. And the question is how do these guidelines fit into that? And should they be adjusted if this is a normal age-related decline?

REHM

10:44:04
Dr. Fugh-Berman?

FUGH-BERMAN

10:44:06
Right. And that's really unclear what are "normal" levels for different ages. So that's really an important question, but also the Endocrine Society takes quite a lot of money from drug companies. And you actually get different answers when you look at who's getting paid.

FUGH-BERMAN

10:44:27
So, for example, there was a meta-analysis of adverse events in testosterone trials and when they divided out the trials into which ones had been funded by pharmaceutical companies that made testosterone and which ones had not, they found that the industry-funded trials found no increased cardiovascular risks, but that the non-industry-funded trials did find an increase in cardiovascular risk. So it's always important to follow the money.

REHM

10:44:52
Did you see that -- hold on, Dr. Fisch. Did you see that, too, Roni, in terms of the kinds of studies being done?

RABIN

10:45:06
Well, the meta-analysis that Adriane talked about, definitely was able to separate it out and saw that the trials that were funded by industry did not see as big an increase as the ones that were independent. And I think we do see this fairly consistently. Even in talking to -- when I do my interviews, I'm always very careful to ask if people have industry ties. And the tone changes dramatically, and it's often consistent with that.

REHM

10:45:36
All right. I want to take another call. This from Louisville, Texas. Hi, Brett. You're on the air.

BRETT

10:45:44
Hi, Diane. My question is -- if you guys could talk about how doctors are actually compensated. My sister-in-law is actually a drug rep. And she says that oftentimes doctors get direct payments for prescribing certain drugs. And they also may get Super Bowl tickets or sports tickets. And if you guys could talk about how that may be influencing some doctors to make some of those decisions, I would appreciate it.

REHM

10:46:07
All right. Roni, I wonder if you've seen any of that.

RABIN

10:46:13
Well, I don't know about direct payments. I wouldn't know how that would happen. There's definitely been a big gift and dinner and lunch industry. And there have been efforts to crack down on that and have more transparent reporting. I think actually one of the most dangerous things is that so much information is coming directly from drug companies to physicians, and there isn't always moderation of that. So there's a lot of education that drug companies are doing of physicians.

REHM

10:46:45
All right.

RABIN

10:46:45
And that education may not be as complete or comprehensive or somewhat biased.

REHM

10:46:49
Dr. Fisch, do you want to comment on the question?

FISCH

10:46:53
Of course, I'd like to comment on the question, Diane. It turns out that giving money or Super Bowl tickets to doctors is illegal. You can't do that. In fact, they don't even give pens out anymore. What they do do is they do sponsor doctors to educate other doctors. And that's where they have the dinner programs and things like that. And I'm all in favor of that. But I could tell you that I know for a fact it is illegal to really compensate doctors for writing prescriptions.

REHM

10:47:19
Dr. Fugh-Berman?

FUGH-BERMAN

10:47:21
It's illegal to pay someone to write prescriptions, but it's not illegal to give gifts at all. And there's many ways in which pharmaceutical companies affect physicians. So not only do drug reps target physicians who control market share or might be writing a lot of branded prescriptions, but also pay physicians to be speakers, they pay them to be consultants, they pay to essentially do fake clinical trials where they're being paid to enroll patients in clinical trials that don't really exist. So there's different ways of paying somebody without it being a direct payment for a prescription.

REHM

10:48:02
Roni, I'm wondering to what extent the studies looked at the number of advertisements on television, correlating them with the increase in use of these prescription drugs.

RABIN

10:48:23
I am not aware of studies that looked at that correlation. Dr. Fugh-Berman may know more about that. There certainly has been an enormous amount of money poured into advertising, about $100 million has been spent on advertising specific brands of drugs. And then there's additional money that's spent on raising awareness of the condition and the disease that's not even tracked the same way. And there's a correlation between that increase and the increase in sales and increase in prescriptions.

FUGH-BERMAN

10:48:57
Yes, absolutely. And, of course, drug companies don't spend money on things that don't work. And direct-to-consumer advertising is important. Those ads are very creative. But in the industry they actually have -- industry says that it's more important to get to the doctors because they're the ones who really have the prescription pad.

FUGH-BERMAN

10:49:16
And certainly it increases the acceptability of therapies to have direct-to-consumer advertising. But as Roni mentioned, medical education or continuing medical education -- a lot of that is funded by pharmaceutical companies. And it always has subtle messages in it that do not necessarily even mention brand names.

FUGH-BERMAN

10:49:38
It's all about what Dr. Fisch called disease awareness, convincing physicians that a particular disease state, as industry calls it, is underdiagnosed, it's affecting a lot more people than we think, that it's having a dramatic effect on people's lives. That's the job of these physicians who are key opinion leaders. It's their job to tell other physicians that a particular disease is underdiagnosed and needs to be treated more often. Low T is a perfect example of that.

REHM

10:50:08
Dr. Fisch, do you want to comment?

FISCH

10:50:10
Of course. Hypogandism is a disease. It's something that has been underdiagnosed in the past.

REHM

10:50:16
But how rare is that, Dr. Fisch?

FISCH

10:50:20
Well, it's not rare in my practice since that's all I do as a fertility doctor. I could tell you that many people who have hypogonadism have low sperm counts and are infertile. Men who have hypogonadism tend to have low libido, sexual dysfunction problems, in addition to a myriad of other problems associated with it. It is real. I'm the only person on this panel that actually treats patients.

FISCH

10:50:40
And as a professor at an Ivy League university, I'm telling you that this is an actual disease and not to make fun of a disease because you're not aware of all of the symptoms or all the problems associated with it. I want to make a point about the studies that say there is a problem. In the Plus One study, I want to make a point that patients treated at the VA center did not have testosterone levels.

FISCH

10:51:01
We don't know if they were men who had normal testosterone levels or below testosterone levels. And only men who were hypogonadal with low testosterone levels should be treated. There are risks associated with these medications for people who should not be treated, who have normal levels and whose levels go into super normal, extra, above normal levels, and that's where you see the problems.

REHM

10:51:21
All right.

FISCH

10:51:22
So a doctor has to be educated and has to know how to treat patients. And patients need to be aware of all the risks and benefits associated with these medications.

REHM

10:51:27
All right. Let me take another call. Dana, in Ft. Worth, Texas, you're on the air.

DANA

10:51:34
Hi. Good morning.

REHM

10:51:36
Hi.

DANA

10:51:38
My sister is 46 and perimenopausal. And she went to a homeopathic doctor, if you will, and was prescribed testosterone injections that she does twice a month. And I'm wondering if any of these studies or side effects are relevant to women?

REHM

10:51:57
Dr. Fugh-Berman?

FUGH-BERMAN

10:51:58
Well, there are these anti-aging clinics that unfortunately will mix together different hormones often in compounded preparations. They might mix estrogen and testosterone and other kinds of things together. So, yeah, this is both in conventional medicine and also in alternative medicine. But there's no such thing as a harmless hormone. Hormones affect the whole body. We know about the problems with menopausal hormone therapy. We're going to see an epidemic of adverse effects from testosterone.

FUGH-BERMAN

10:52:30
In women, the FDA has actually turned down several -- well, they turned down testosterone treatment for libido in women because it didn't work very well and they were concerned about safety. Women with higher testosterone levels, naturally-occurring testosterone levels, for example, have higher breast cancer rates. And there was just a testosterone gel study in women that was stopped also for lack of efficacy.

REHM

10:52:55
And you're listening to "The Diane Rehm Show." Let's go to Jim in Tallahassee, Fla. You're on the air.

JIM

10:53:06
Hi, Diane.

REHM

10:53:07
Hi.

JIM

10:53:08
You deserve a medal. I recall a parallel discussion on your show about women and calcium levels. And it seems as if the pharmaceutical companies were creating these classes of patients who were not quite ill or diseased, but feel that they need to be treated. My calcium's low. I should be taking some sort of supplement. And I'm wondering that this low T thing doesn't strike very similar chords of trying to get people who may not have disease wanting to treat their fatigue or their, you know…

REHM

10:53:54
All right. Thanks for your call. Dr. Fugh-Berman?

FUGH-BERMAN

10:53:57
Sure. It's a really great point because there is a lot more well people than there are sick people. So well people are a much larger market. And if pharmaceutical companies can convince people who are perfectly healthy that they need a drug, they can sell a lot more of that drug.

REHM

10:54:14
All right. To David, in Lillian, Ala. You're on the air.

DAVID

10:54:21
Good morning.

REHM

10:54:21
Hi.

DAVID

10:54:22
I've been through the ringer on this. I'm 60 years old in two days, and in 1995, exactly to the day of my birthday, I went for an operation. I tore a solar plex muscle in the Marine Corps, and I put up with it since '74 until '95. The guy did the surgery. It went horribly wrong. They left a twist tie on the vas deferens. The gonad swelled up to giant, and it stayed like that for 20 months. Hard as stone and months later, I went and saw a urologist. She put me on testosterone.

DAVID

10:54:53
She said, there's nothing we can do now. They should have opened you up and took the twist tie off of there. She goes, why was it on there in the first place? I didn't know. I've got a picture of it. And there was nothing I could do about it. But I've been taking the testosterone cypionate, and I got down to a half cc every 10 days.

DAVID

10:55:09
And I've been doing this for all these years. I can't find out what exactly it's made out of. Synthetics, they told me -- was best I could come up with for an answer. Does it cause tumors on organs? I've heard of heart disease three times greater. I was a distance runner. I've gone up and down with the mood swings and all the weight.

REHM

10:55:27
All right. David, it sounds as though you've got multiple problems going on. And I do hope you'll continue to check in with your own doctor. What would you say to him, Dr. Fisch?

FISCH

10:55:45
Well, it sounds like David had a testicular problem and probably had low testosterone -- although I am not his doctor. But if you're losing a testicle, remember, that's the organ that makes testosterone. So you very likely had hypogonadism. And the medication for him may have helped some of his symptoms. But of course once you're on this medication you need to have follow-up with, again, testosterone levels and red blood cell counts and estrogen levels to see if they're increased in any way because those -- if it's increased you need other treatment to avoid those increases.

REHM

10:56:16
All right.

FISCH

10:56:16
And, as said, the injections are the ones that cause more problems than if it's in the normal range.

REHM

10:56:20
All right. And finally, Dr. Fugh-Berman, do you believe that this is a drug looking for a disease?

FUGH-BERMAN

10:56:34
Yes, absolutely. It used to be before we had these gels that were injections. And there certainly were companies trying to sell the concept of male menopause or andropause to men, but it's hard to get them to take injections. So since they've been available in gels it's really increased the market and increased the opportunities for creating a disease state in men.

REHM

10:56:55
So you believe there have got to be lots more studies?

FUGH-BERMAN

10:57:01
No. I actually think we have enough studies to say healthy men shouldn't use this.

REHM

10:57:04
All right.

FISCH

10:57:04
That's true.

REHM

10:57:06
Dr. Adriane Fugh-Berman of Georgetown University, Dr. Harry Fisch -- he's professor of urology and reproductive medicine at New York Hospital and Cornell University -- and Roni Caryn Rabin, medical reporter in the New York Times, thank you all so much.

FUGH-BERMAN

10:57:30
Thank you.

FISCH

10:57:31
Thank you.

RABIN

10:57:31
Thank you.
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