sen rand paul r tb KY is a PUSSY (pussy3[poo s-ee] Slang: a timid, passive, or effeminate man.), a fear mongering coward and a hypocrite because he is one of the leaders of the gop / tea-bagger / grover norquist federal budget cutting cabal in congress. He is too pompous to be ashamed of his words and actions that are fueling unnecessary panic over Ebola, but he should be. The next time he starts running his mouth about Ebola and the inadequate federal government response someone should bitch slap him. This from +Mother Jones followed by a couple of reports from the +PBS NewsHour explaining just how Ebola is transmitted.
Sen.
Rand Paul (R-Ky) reportedly put on his scientist hat this morning,
telling CNN's Ashley Killough that Ebola is more easily spread than
AIDS–a statement that is an irresponsible, flat out lie.
Ashley Killough ✔ @KilloughCNN Follow
Paul's posturing is just the latest in a series of Ebola-truthing tactics he and other members of the GOP have been fully employing as of late. Perhaps more seriously, Paul's theory calls into question the types of feverish, vomit-spewing cocktail soirees he suggests he frequents.
For a deeper look into the contagiousness of Ebola compared to other diseases, check out the charts below from David McCandless and NPR:
| Thu Oct. 16, 2014 2:08 PM EDT
Ashley Killough ✔ @KilloughCNN Follow
Rand Paul tells me Ebola more
transmitable than AIDS. "If someone has Ebola at a cocktail party,
they're contagious and you can catch it."
Paul's posturing is just the latest in a series of Ebola-truthing tactics he and other members of the GOP have been fully employing as of late. Perhaps more seriously, Paul's theory calls into question the types of feverish, vomit-spewing cocktail soirees he suggests he frequents.
For a deeper look into the contagiousness of Ebola compared to other diseases, check out the charts below from David McCandless and NPR:
Adam Serwer ✔
@AdamSerwer
Follow
My @'s are filling with lots of derp about Ebola being more contagious than HIV. Here you go. http://www.npr.org/blogs/health/2014/10/02/352983774/no-seriously-how-contagious-is-ebola …
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A new survey finds the public has a lot to learn about how the Ebola virus is transmitted, which could help explain the growing fears of the disease.
The survey by the Kaiser Family Foundation found that while nearly all adults (97 percent) know a person can become infected through direct contact with the blood or other body fluids of someone who is sick with Ebola, there are still misconceptions. (KHN is an editorially independent program of the foundation.)
One third of respondents are unaware they cannot become infected through the air. About 45 percent are unaware they cannot contract Ebola by shaking hands with someone who has been exposed to the virus but who does not have symptoms.
And only slightly more than a third (36 percent) of respondents know that a person must be showing Ebola symptoms to transmit the infection, the poll found.
The survey, which was fielded after a Liberian man was diagnosed with Ebola in Dallas, and remained in the field after a nurse who helped care for him contracted the disease, finds most Americans say they trust local, state, and federal health authorities to contain the disease in the U.S.
The public was near evenly split on the federal government’s response to the crisis. About 45 percent said the government was doing enough to fight the disease in Africa and 48 percent said it was doing enough to protect Americans.
The telephone poll of 1,503 adults was conducted from October 8-14 and has a margin of error was plus or minus 3 percentage points.
Kaiser Health News is an editorially independent program of the Henry J. Kaiser Family Foundation, a nonprofit, nonpartisan health policy research and communication organization not affiliated with Kaiser Permanente.This is how you get Ebola, as explained by science
September 30, 2014 at 8:24 PM EDTThis post was originally published on Aug. 21 and updated on Sep. 30 to reflect the latest numbers from the World Health Organization.A colorized, magnified electron microscope image of the Ebola virus growing out of an infected VERO 46 cell. Image by National Institute of Allerfy and Infectious Diseases
As of Sep. 30, the Ebola virus had killed more than 3,000 people in the West African countries of Liberia, Sierra Leone, Guinea and Nigeria, according to the latest numbers released by the World Health Organization.
As the virus spreads and medical workers feverishly battle to contain it, we wanted to know, how exactly is this virus transmitted from human to human?
What is Ebola?
Ebola is one of the world’s most virulent diseases. It comes from an extended family of viruses called Filoviridae, which also include the deadly Marburg virus. It is a swift and effective killer, known to kill up to 90 percent of those it infects. And it is a “hemorrhagic fever virus,” which means it causes fluid to leak from blood vessels, resulting in a dangerously low drop in blood pressure.Illustrations by Ruth Tam
Understanding Ebola requires an understanding of viruses and how they work. “Viruses,” science writer Carl Zimmer writes in his book “A Planet of Viruses”, “can replicate themselves, despite their paltry genetic instructions, by hijacking other forms of life. They… inject their genes and proteins into a host cell, which they [manipulate] into producing new copies of the virus. One virus might go into a cell, and within a day, a thousand viruses [come] out.”
All viruses contain “attachment proteins,” which, as the name suggests, attach to host cells through the cells’ “receptor sites.” This is how they invade healthy human cells.
While some virus particles are shaped like spheres, the particles that make up Ebola are filament-like in structure, giving them more surface area to potentially attack a greater number of cells. Each Ebola virus particle is covered in a membrane of these attachment proteins, or glycoproteins.
“[The virus] has a tremendous number of glycoproteins, which can increase its ability to affect cells,” said Richard Cummings, chair of Emory’s Dept. of Biochemistry and director of the National Center for Functional Glycomics. “It’s extremely infectious in that regard.”
Imagine Ebola’s glycoproteins as giant oak trees with branches and leaves, said Erica Ollmann Saphire, a structural biologist at the Scripps Research Institute. The Ebola virus has its own critical receptor site, which lies beneath these branches and leaves to avoid detection from the immune system. Each glycoprotein can attach itself to a host cell in a number of different ways, but once its branches fasten themselves to a host cell’s molecules, that host cell pulls in the attachment protein, slicing off its leaves and branches and exposing the trunk, the virus’s receptor site.
“The previously hidden receptor rearranges itself and spring loads like a spear fishing rod,” said Saphire. “It uncoils, springs forward and penetrates the membrane, driving itself into the cytoplasm.”
The cells then internalize the virus, and Ebola’s race against the human immune system begins.
How Ebola moves from person to person
Ebola spreads through direct contact with infected bodily fluids or tissue. The virus can be transmitted when an infected person’s vomit, blood or other fluids contact another person’s mouth, eyes or openings in their skin, said Dr. Ameesh Mehta, an infectious disease doctor at Emory University.
Even after a person has died, the virus persists. In West Africa where funeral rites include washing, touching and kissing corpses by family members, putting the dead to rest can be just as deadly as caring for a living patient.
“Contact with any aspect of it is considered very dangerous,” Cummings said. “Any physical contact.”
Ebola’s sucker punch is its speed of replication. At the time of death, a patient can have 1 billion copies of the virus in one cubic centimeter of blood. In comparison, HIV, a similar virus, has the same rate at the time of death. But unlike HIV, which only infects two types of immune cells, Ebola first infects white blood cells that disable the body’s ability to destroy foreign substances, then seizes nearly every cell type.
“It’s a systemic viral infection throughout your body as opposed to an infection of just your immune system,” Saphire said. “Patients may die before they’re able to mount much of an immune response.”
This process takes anywhere from two to 21 days (though it’s typically between four to 10 days). When the immune system begins breaking down, the symptoms begin to show.
Patients experience fevers, headaches and fatigue early on. After the virus overwhelms healthy cells, they burst, causing a chemical release leading to inflammation. Their remains are taken over by other cells, perpetuating the virus. As the symptoms worsen, patients suffer from bloody diarrhea, severe sore throat, jaundice, vomiting or loss of appetite.
Infected cells that haven’t yet burst carry the virus through the bloodstream to invade different parts of the body like the lymph nodes, spleen and liver. When infected cells attach themselves to the inside of blood vessels, it weakens them, causing fluids to leak. This triggers the uncontrollable bleeding for which Ebola is known, though it only happens for about 50 percent of patients and occurs mostly inside the body.
In fatal cases, blood pressure plummets after blood vessel damage, and death from shock or multiple organ failure occurs within six to 16 days.
The path ahead
Saphire is part of a large, multi-site team made up of 25 laboratories that’s mapping Ebola’s glycoprotein to better understand and defeat the virus. Among the potential strategies they’re studying is an antibody cocktail called ZMapp, an experimental drug that drew media attention after its use on two U.S. aid workers and three Liberian doctors. First developed by the U.S. Army Medical Research Institute for Infectious Diseases a decade ago, this “Ebola serum” potentially works to neutralize the virus by preventing its rearrangement and flagging it for destruction by the immune system.
Clinical trials for ZMapp are set to begin in 2015, but according to Saphire, doses for “experimental compassionate therapy,” treatment provided to critically-ill patients before the drug has been approved, could be ready in three months.
“The central dogma of molecular biology is that sequence dictates fold, which dictates function,” Saphire said. “But Ebola does more with less. While the human genome has 20,000 kinds of genes, Ebola has seven, and by rearranging its protein structure, it can carry out far more than seven functions.”
Ebola, Saphire explained, remodels its molecules “like a Transformer: those toys that unfold and refold to change between a robot and a truck,” she said. “We don’t typically expect molecules in biology to do that. We expect proteins to have one particular form – just the robot. If you didn’t know that the Ebola robot would also refold into a truck, you would design all your drugs against the robot structure.”
In addition, due to its extreme nature, there are far fewer human studies on Ebola than other similar viruses.
“Ebola patients are often too sick to consent to research,” Mehta said. These cases are occurring in poor environments where it’s hard to collect the samples to really understand the pathogens. But hopefully science catches up with the clinical phenomenon.”
While the recent outbreak is not expected to reach far beyond West Africa, researchers like science writer Richard Preston fear the beginning of a more deadly and longer-lasting epidemic if the virus finds its way to metropolitan areas like Lagos, Nigeria, which has a population larger than the state of New York.
Despite Ebola’s pervasive spread, Cummings says the biggest misconceptions are that Ebola is easily transmitted and that the outbreak in West Africa could reach global levels.
While one should still exercise caution, Cummings says the requirement of transmission of fluids makes the disease more difficult to get if you’re not directly treating patients.
“It is more controllable than people realize.”
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